Despero was created by Bernard Sachs, Gardner Fox and Mike Sekowsky. He made his first appearance as an enemy of the Justice League in Justice League of America #1 - The World of No Return! Despero is the tyrant ruler of Kalanor who has fought the Justice League on numerous occasions. He is one of their first villains and has appeared repeatedly throughout their history. Though he first appeared as a pink skinned alien genius who had a third eye that granted him hypnotic powers, he is now one of the most physically powerful villains the League as ever faced while at the same time retaining all his mental abilities. His new found power comes from recreating himself in the Flame of Py'tar, which was the last remnant of the same nuclear energy responsible for creating his race.